NR AHZM
AU Massimino,M.L.; Griffoni,C.; Spisni,E.; Toni,M.; Tomasi,V.
TI Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis
QU Cellular Signalling 2002 Feb; 14(2): 93-8
PT journal article; review; review, tutorial
AB Caveolae, the flask-shaped membrane invaginations abundant in endothelial cells, have acquired a prominent role in signal transduction. Evidence, that events occurring in caveolae participate in cell survival and angiogenesis, has been recently substantiated by the identification of two novel caveolar constituents: prostacyclin synthase (PGIS) and the cellular form of prion protein (PrPc). We have shown that PGIS, previously described as an endoplasmic reticulum component, is bound to caveolin-1 (cav-1) and localized in caveolae in human endothelial cells. By generating prostacyclin, PGIS is involved in angiogenesis. Previous observations regarding the localization of PrPc in caveolae-like membrane domains (CLDs) have been recently confirmed and extended. It has been demonstrated that PrPc is bound to cav-1 and, by recruiting Fyn kinase, can participate in signal transduction events connected to cell survival and differentiation. The new entries of PGIS and PrPc in caveolar components place caveolae and CLDs at the centre of a network, where cells decide whether to proliferate or differentiate and whether to survive or to suicide by apoptosis.
ZR 72
IN Die in endothelialen Zellen häufigen Caveolen spielen eine wichtige Rolle in der Rezeptor-vermittelten Signalübertragung. Die Entdeckung der Prostacyclinsynthase (PGIS) und ihrer Bindung an Caveolin-1 in den Caveolen von Endothelzellen spricht auch für eine Rolle in der Gefäßbildung. Aber auch das zelluläre Prionprotein wurde in Caveolen gefunden und es bindet dort ebenfalls an Caveolin-1. Unter Mitwirkung der Fyn-Kinase scheint es an der Übertragung von Signalen zur Zelldifferenzierung und der Entscheidung zwischen Weiterleben und Apoptose beteiligt zu sein.
MH Animal; Binding Sites; Caveolae/chemistry/*physiology; Caveolins/metabolism; Cell Survival; Cytochrome P-450 Enzyme System/chemistry/physiology; Human; Intramolecular Oxidoreductases/chemistry/physiology; Mice; Neovascularization, Physiologic; PrPc Proteins/chemistry/physiology; Protein Structure, Tertiary; *Signal Transduction
AD
Maria Lina Massimino, Department of Biochemistry, University of Padova, Padua 35121, Italy
Cristiana Griffoni, Enzo Spisni, Mattia Toni, Vittorio Tomasi, Department of Experimental Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
SP englisch
PO England
ZF kritische Zusammenfassung von Roland Heynkes