NR AHWN
AU Marsh,R.F.; Bessen,R.A.
TI Physicochemical and biological characterizations of distinct strains of the transmissible mink encephalopathy agent
QU Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 1994 Mar 29; 343(1306): 413-4
IA http://www.journals.royalsoc.ac.uk/media/hb5c1xjvuhcxuv9rpv5m/contributions/u/7/8/h/u78h876734285p13.pdf
PT journal article
AB Inoculation of the Stetsonville, Wisconsin source of transmissible mink encephalopathy (TME) into Syrian hamsters has identified two strains of the TME agent having distinct biological properties and producing disease-specific prion proteins (PrPTME) having different physicochemical properties. Although several strains of the sheep scrapie agent have been identified in Great Britain, this is the first indication that agents producing transmissible spongiform encephalopathies in the United States also are capable of producing distinct strains.
IN Die Infizierung syrischer Hamster mit der übertragbaren Nerz-Enzephalopathie zeigte, dass es auch hier unterschiedlich wirkende Krankheitsüberträger gibt.
MH Animal; Chemistry, Physical; Comparative Study; Endopeptidases/metabolism; Hamsters; Mesocricetus; *Mink; PrPsc Proteins; Prion Diseases/*etiology/metabolism/transmission; Prions/*chemistry/metabolism; Time Factors
AD R.F. Marsh, Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706 USA
SP englisch
PO England