NR AHNV
AU Lovestone,S.; McLoughlin,D.M.
TI Protein aggregates and dementia: is there a common toxicity?
QU Journal of Neurology, Neurosurgery and Psychiatry 2002 Feb; 72(2): 152-61
PT journal article; review; review, tutorial
AB This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD) - beta-amyloid peptide and tau - but also considers other proteins in this disorder and in less common but equally devastating diseases.
ZR 125
MH Alzheimer Disease/*pathology; Amyloid/metabolism; Brain/pathology; Extracellular Space; Human; Inclusion Bodies/pathology; Nerve Tissue Proteins/metabolism; Neurodegenerative Diseases/*pathology; Nuclear Proteins/metabolism; Peptide Fragments/metabolism; Prions/metabolism; Proteins/*metabolism; Support, Non-U.S. Gov't; tau Proteins/metabolism
AD Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. s.lovestone@iop.kcl.ac.uk
SP englisch
PO England