NR AHMX
AU Loginova,N.V.; Cherednichenko,Iu.N.; Viazov,S.O.; Vanag,K.A.; Zhdanov,V.M.
TI [Infectious activity of cell fractions isolated from the brain of mice with scrapie]
OT Infektsionnaia aktivnost' fraktsii kletok, vydelennykh iz mozga myshei, bol'nykh skrepi
QU Voprosy Virusologii 1983 Sep-Oct; 28(5): 597-601
PT journal article
AB The agent of scrapie was found to induce clinically similar diseases in BALB/c and NIH mice but differing in the duration of the incubation period (155-180 days and 110-140 days, respectively) and pathomorphological manifestations. Differentiated examinations of a brain cell pool from mice with scrapie revealed more infectious activity not neutralized with nucleases and pronasa in membrane-free cell fractions than in fractions of slowly sedimenting membranes.
MH Animal; Brain/*microbiology/ultrastructure; Cell Fractionation; Comparative Study; Disease Models, Animal; English Abstract; Mice; Mice, Inbred BALB C; Organoids/microbiology; Scrapie/*etiology/microbiology/pathology; Sheep; Time Factors
SP russisch
PO Sowjetunion