NR AHKZ
AU Link,C.D.
TI Transgenic invertebrate models of age-associated neurodegenerative diseases
QU Mechanisms of Ageing and Development 2001 Sep 30; 122(14): 1639-49
PT journal article; review; review, tutorial
AB Transgenic Drosophila melanogaster and Caenorhabditis elegans strains have been engineered to express human proteins associated with neurodegenerative diseases. These model systems include transgenic animals expressing beta-amyloid peptide (Alzheimer's disease), polyglutamine repeat proteins (Huntington's disease, Spinocerebellar ataxia), and alpha-synuclein (Parkinson's disease). In most of these invertebrate models, some aspects of the human diseases are reproduced. Although expression of all these proteins in transgenic mice has been instructive, the invertebrate models offer experimental advantages (e.g. forward genetic screens) that can potentially address some of the outstanding questions regarding the cellular processes underlying these diseases. This review considers what has been learned from these invertebrate models, and speculates what further insight may be gained from them.
ZR 24
MH Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animal; Animals, Genetically Modified; Caenorhabditis elegans; *Disease Models, Animal; Drosophila melanogaster; Human; *Neurodegenerative Diseases; Parkinson Disease; Prion Diseases
AD Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309, USA. linkc@colorado.edu
SP englisch
PO Irland