NR AHIY
AU Liberski,P.P.; Yanagihara,R.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Tubulovesicular structures in experimental Creutzfeldt-Jakob disease and scrapie
QU Intervirology 1988; 29(2): 115-9
PT journal article
AB Tubulovesicular structures, measuring 20-50 nm in diameter, were found in dilated neuronal processes in brains from mice infected with the Fujisaki strain of Creutzfeldt-Jakob disease virus. These particles were similar to those observed in brains from hamsters infected with scrapie. These structures are consistently present in naturally occurring and experimentally induced spongiform encephalopathies, irrespective of the host species or virus strain. Their role in pathogenesis is undetermined.
MH Animal; Creutzfeldt-Jakob Syndrome/*microbiology/pathology; Hamsters; Inclusion Bodies, Viral/*ultrastructure; Mesocricetus; Mice; Microscopy, Electron; Prions/ultrastructure; Scrapie/*microbiology/pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Laboratory of Central Nervous System Studies, National Institutes of Health, Bethesda, Md 20892.
SP englisch
PO Schweiz