NR AHIM
AU Liberski,P.P.; Yanagihara,R.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Experimental Creutzfeldt-Jakob disease: light microscopic, immunohistochemical and ultrastructural studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in NIH Swiss mice.
QU Neuropatologia Polska 1991; 29(1-2): 1-17
PT journal article
AB Ultrastructural findings in mice terminally affected with the Fujisaki strain of Creutzfeldt-Jakob disease virus are reported. Spongiform vacuolation, extensive myelin and axonal lesions and neuroaxonal dystrophy accompanied by abundant astrocytic gliosis comprise the pattern of the pathological changes at the ultrastructural level. Neuronal intranuclear inclusions and swelling of the astrocytic and dendritic processes were unspecific findings also observed in control animals.
MH Animal; Brain/metabolism/microbiology/*pathology/ultrastructure; Creutzfeldt-Jakob Syndrome/metabolism/microbiology/*pathology; *Disease Models, Animal; Glial Fibrillary Acidic Protein/metabolism; Immunohistochemistry; Inclusion Bodies, Viral/*ultrastructure; Mice; Microscopy, Electron; Myelin Sheath/ultrastructure; Neurons/metabolism/microbiology/*pathology/ultrastructure; Organelles/ultrastructure; Prions/*isolation & purification/ultrastructure; Support, Non-U.S. Gov't
AD Department of Oncology, School of Medicine, Lodz, Poland.
SP englisch
PO Polen