NR AHHM
AU Liberski,P.P.; Sklodowski,P.; Klimek,A.
TI Creutzfeldt-Jakob disease: ultrastructural study of brain biopsy: unusual interaction between astrocytes and oligo- and microglia.
QU Folia Neuropathologica 1995; 33(2): 85-92
PT journal article
AB We report a case of Creutzfeldt-Jakob (CJD) disease in a 72-year-old man without characteristic EEG alterations. Unusually abundant pleomorphic PrP-immunopositive amyloid plaques were found in the cerebellum. Despite of this similarity with Gerstmann-Sträussler-Scheinker (GSS) disease the case cannot be classified as GSS lacking classical GSS 102 PRNP gene mutation. The ultrastructural findings were similar to those described previously for CJD. The close contact of reactive astrocytes with both oligodendroglia and microglia in this case suggests their possible functional interaction.
IN Ein 72-jähriger Creutzfeldt-Jakob-Patient mit vielen amyloiden Plaques im Kleinhirn zeigte kein charakteristisches EEG-Muster. Reaktive Astrzyten wurden in engem Kontakt mit Oligodendrozyten und Mikroglia gefunden. (Laut Pschyrembel gehören neben den Hortegazellen auch die Oligodendrozyten zu den Mikroglia.)
ZR 27
MH Aged; Astrocytes/*ultrastructure; Brain/physiopathology/*ultrastructure; Case Report; Creutzfeldt-Jakob Syndrome/*diagnosis/physiopathology; Human; Male; Microglia/*ultrastructure; Support, Non-U.S. Gov't
AD Laboratory of Electron Microscopy and Neuropathology, School of Medicine, Lodz.
SP englisch
PO Polen