NR AHGV
AU Liberski,P.P.; Ironside,J.; McCardle,L.; Sherring,A.
TI Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease
QU Folia Neuropathologica 2000; 38(4): 167-70
PT journal article
AB We report here the first description of florid plaques - the hallmark of variant Creutzfeldt-Jakob disease (vCJD). These plaques are composed of broad bundles of amyloid, are highly neuritic and exhibited astrocytes and microglial cells. Collectively, they are more similar to neuritic plaques of Alzheimer's disease than to kuru plaques of kuru - Creutzfeldt-Jakob disease - Gerstmann-Sträussler-Sheinker disease.
MH Alzheimer Disease/pathology; Amyloid/analysis; Astrocytes/ultrastructure; Brain/*pathology; Comparative Study; Creutzfeldt-Jakob Syndrome/*pathology; Human; Kuru/pathology; Microglia/ultrastructure; Microscopy, Electron; Neurites/ultrastructure; Senile Plaques/chemistry/*ultrastructure
AD Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland. ppliber@psk2.am.lodz.pl
SP englisch
PO Polen