NR AHGL
AU Liberski,P.P.; Jaskolski,M.
TI Prion diseases: a dual view of the prion hypothesis as seen from a distance.
QU Acta Neurobiologiae Experimentalis 2002; 62(3): 197-224; discussion 224-6
PT journal article; review; review, tutorial
AB We review the historical background and principles of the prion theory in its current shape. We showed that most of data may be still interpreted dually according to the protein only hypothesis and according to the theory in which additional component is necessary to comprise the infectivity. The enormous impact of structural biological studies is also stressed.
ZR 280
MH Animal; Goats; Human; Kuru/pathology/transmission; Mutation; Phenotype; Prion Diseases/genetics/pathology/*transmission; Prions/*genetics/pathogenicity; Protein Conformation; Scrapie/pathology/transmission; Support, Non-U.S. Gov't
AD Laboratory of Electron Microscopic and Neuropathology, Department of Molecular Biology, Medical Academy Lodz, Department of Neurosurgery, Polish Mother Memorial Hospital, Lodz, Poland. ppliber@csk.am.lodz.pl
SP englisch
PO Polen