NR AHGG
AU Liao,Y.C.; Lebo,R.V.; Clawson,G.A.; Smuckler,E.A.
TI Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications.
QU Science 1986 Jul 18; 233(4761): 364-7
PT journal article
AB A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Sträussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.
MH Amino Acid Sequence; Animal; Base Sequence; Chromosome Mapping; Chromosomes, Human, 19-20; Chromosomes, Human, 21-22 and Y; *Cloning, Molecular; Creutzfeldt-Jakob Syndrome/genetics/microbiology; DNA/*analysis; DNA Restriction Enzymes/metabolism; Hamsters; Human; Prions/*genetics; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Viral Proteins/analysis
SP englisch
PO USA