NR AHAH
AU Lantos,P.L.; McGill,I.S.; Janota,I.; Doey,L.J.; Collinge,J.; Bruce,M.T.; Whatley,S.A.; Anderton,B.H.; Clinton,J.; Roberts,G.W.; et al.
TI Prion protein immunocytochemistry helps to establish the true incidence of prion diseases
QU Neuroscience Letters 1992 Nov 23; 147(1): 67-71
PT journal article
AB Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSSD) are transmissible spongiform encephalopathies or prion diseases affecting man. It has been reported that prion diseases may occur without the histological hallmarks of spongiform encephalopathies: vacuolation of the cerebral grey matter, neuronal loss and astrocytosis. These cases without characteristic neuropathology may go undiagnosed and consequently the true incidence of transmissible dementias is likely to have been under-estimated. Immunocytochemistry using antibodies to prion protein gives positive staining of these cases, albeit the pattern of immunostaining differs from that seen in typical forms. Accumulation of prion protein is a molecular hallmark of prion diseases, and thus a reproducible, speedy and cost-efficient immunocytochemical screening of unusual dementias may help to establish the true incidence of prion diseases.
MH Adult; Base Sequence; Biological Markers; Human; Immunohistochemistry; Male; Molecular Sequence Data; Prion Diseases/*epidemiology/immunology/pathology; Prions/*immunology/*metabolism; Proteins/immunology/*metabolism; Support, Non-U.S. Gov't
AD Department of Neuropathology, Institute of Psychiatry, London, UK
SP englisch
PO Niederlande