NR AHAC
AU Lansbury,P.T.Jr.; Caughey,B.W.
TI The chemistry of scrapie infection: implications of the 'ice 9' metaphor.
QU Chemistry and Biology 1995 Jan; 2(1): 1-5
PT journal article; review; review, tutorial
AB The transmissible spongiform encephalopathies pose an increasing problem for animal, and perhaps human, health. The infectious agent seems to lack a nucleic acid component, posing the question of how it can reproduce. A model of reproduction by nucleated polymerization suggests a number of novel approaches to the problem.
ZR 44
MH Animal; Human; Models, Chemical; Nucleic Acids/*physiology; PrPsc Proteins/*chemistry/genetics; Scrapie/transmission
AD Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA
SP englisch
PO England