NR AGWI
AU Kulczycki,J.
TI [Creutzfeldt-Jakob disease: the most frequent spongiform encephalopathy in humans]
OT Choroba Creutzfeldta-Jakoba - najszerzej wystepujaca u ludzi encefalopatia gabczasta
QU Przeglad Epidemiologiczny 2001; 55(1-2): 177-82
PT journal article
AB Creutzfeldt-Jakob disease (CJD) which for many years was interpreted as one of degenerative brain processes is the most frequent spongiform encephalopathy caused by prions - molecules of erroneously conformed protein. In only few percent ill people occurrence of this pathogenic factor occurs as a result of mutation in gene PrP. Because transmissibility of prions was proved it should be supposed that in other cases CJD is a result of "infection" Susceptibility to prions depends in large part on specificity of host proteins. It creates certain individual and species specific barriers. At the present time we witness, fortunately only in single cases, occurrence in people variant CJD caused by prions originated from animals affected by "mad cow disease". Prognosis for human population is dependent on the effectiveness of between species barrier for prions.
MH Adult; Creutzfeldt-Jakob Syndrome/*epidemiology; English Abstract; Human; Incidence; Poland/epidemiology
SP polnisch
PO Polen