NR AGUV
AU Kretzschmar,H.A.; Tings,T.; Madlung,A.; Giese,A.; Herms,J.W.
TI Function of PrPc as a copper-binding protein at the synapse
QU Archives of Virology. Supplementum 2000(16): 239-49
PT journal article; review; review, tutorial
AB The prion protein (PrPc) shows cooperative copper binding of the N-terminal octarepeat (PHGGGWGO) x4. In brain homogenates, PrPc is found in highest concentration in synaptosomal fractions. Mice devoid of PrPc (Prnp0/0 mice) show synaptosomal copper concentrations diminished by 50% as compared to normal mice. PrPc in the synaptic cleft may serve as a copper buffer. Alternatively it may play a role in the re-uptake of copper into the presynapse or may be of structural importance for the N-terminus and thus may influence binding of PrPc to other proteins.
ZR 53
MH Animal; Brain/*metabolism; Carrier Proteins/*metabolism; Copper/metabolism; Mice; Mice, Knockout; Mice, Transgenic; PrPc Proteins/genetics/*metabolism; Support, Non-U.S. Gov't; Synapses/*metabolism
AD Institute of Neuropathology, University of Göttingen, Germany.
SP englisch
PO Österreich