NR AGPL
AU Knight,R.S.G.
TI The relationship between new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy
QU Vox Sanguinis 1999; 76(4): 203-8
PT journal article; review; review, tutorial
AB Creutzfeldt-Jakob disease (CJD) has been transmitted in the laboratory and also by iatrogenic accident. However, research has failed to find evidence that its most common form (sporadic CJD) is a natural infection and, in particular, that there is a causal link with scrapie. Bovine spongiform encephalopathy (BSE) probably resulted from scrapie infection in cattle food. In the wake of the BSE epidemic, a novel clinico-pathological form of CJD has been recognized: new variant CJD (nvCJD). This paper reviews the relationship between nvCJD and BSE and presents the accumulated evidence supporting the view that nvCJD resulted from BSE contamination of human food.
ZR 22
MH Animal; Cattle; Creutzfeldt-Jakob Syndrome/*etiology/*genetics; Encephalopathy, Bovine Spongiform/*complications/*transmission; Human; Variation (Genetics)
AD National CJD Surveillance Unit, Western General Hospital, and Department of Clinical Neuroscience, University of Edinburgh, UK. R.Knight@ed.ac.uk
SP englisch
PO Schweiz