NR AGMV
AU Kirshner,H.S.; Tanridag,O.; Thurman,L.; Whetsell,W.O.Jr.
TI Progressive aphasia without dementia: two cases with focal spongiform degeneration.
QU Annals of Neurology 1987 Oct; 22(4): 527-32
PT journal article
AB Two patients with the syndrome of progressive aphasia without evidence of generalized dementia underwent postmortem neuropathological examinations. In both patients, characteristic changes of Alzheimer's disease, Pick's disease, or Creutzfeldt-Jakob disease were absent. Both patients showed a focal spongiform change involving primarily layer 2 of the left inferior frontal gyrus (and temporal cortex in Patient 1) and a mild astrocytosis in layer 2 and deeper cortical layers. This focal, spongiform cortical degeneration in patients with progressive aphasia does not appear to duplicate any known central nervous system degenerative disease.
MH Aphasia/*complications/pathology; Atrophy; Brain Diseases/complications/*pathology; Case Report; Cerebral Cortex/*pathology; Frontal Lobe/pathology; Gliosis/pathology; Human; Male; Middle Age; Syndrome; Temporal Lobe/pathology
AD Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN.
SP englisch
PO USA