NR AGKY
AU Kimberlin,R.H.; Collis,S.C.; Walker,C.A.
TI Profiles of brain glycosidase activity in cuprizone-fed Syrian hamsters and in scrapie-affected mice, rats, Chinese hamsters and Syrian hamsters
QU Journal of Comparative Pathology 1976 Jan; 86(1): 135-42
PT journal article
AB The profiles of altered activity of 11 brain glycosidases were determined in mice, rats, Syrian hamsters and Chinese hamsters in the clinical stage of infection with the "Chandler" strain of scrapie. The results indicate differences between mice and Syrian hamsters in their response to scrapie infection. Syrian hamsters fed on a diet containing 3.0 per cent. cuprizone (biscyclohexanoneoxaldihydrazone) for 20 to 70 days developed widespread lesions in the brain consisting of vacuolation and astrocyte hypertrophy. The enzyme profile in the brains of cuprizone-fed hamsters was similar to that found in scrapie-affected hamsters. These and previous studies indicate that cuprizone toxicity can provide a useful control for some of the secondary damage produced by scrapie infection in at least two species, mice and hamsters.
IN Mit Maus-Scrapie des Erregerstammes Chandler wurden Mäuse, Ratten, syrische Goldhamster und chinesische Zwerghamster infiziert.
MH Animal; Brain/*enzymology/pathology; Brain Diseases/chemically induced/*enzymology/pathology; Comparative Study; Cuprizone/*toxicity; Cyclohexanes/*toxicity; Galactosaminidase/metabolism; Glucosaminidase/metabolism; Glucuronidase/metabolism; Glycoside Hydrolases/*metabolism; Hamsters; Mannosidases/metabolism; Mice; Rats; Scrapie/*enzymology; Sheep
AD R. H. Kimberlin, Susan C. Collis and Carol A. Walker, A.R.C. Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, UK
SP englisch
PO England