NR AGKW
AU Kimberlin,R.H.; Walker,C.A.
TI Characteristics of a short incubation model of scrapie in the golden hamster
QU Journal of General Virology 1977 Feb; 34(2): 295-304
PT journal article
AB Repeated passage of the "Chandler" strain of scrapie in female golden hamsters using the intracerebral route of inoculation reduces the minimum incubation period to 60 days, about half of the minimum incubation period so far found in any of the mouse models of scrapie. The infectivity titres in brain in the clinical stage of the disease are considerably higher (greater than 8-0 -log10 LD50 i.c. units/0-05 g) than those found in mouse scrapie. The biological characteristics of this model of hamster scrapie are reported, including the effects on incubation period of route of inoculation, dose of agent, sex of hamster, ambient temperature (hibernation) and splenectomy. Some general and specific applications of this experimental model of scrapie are discussed.
IN Laut Kimberlin und Walker [AGKU,1978] und Safar et al. [ASXU,2005] beschreibt dieser Artikel die Isolierung des Hamster-adaptierten Scrapie-Stammes 263K. Laut Walis et al. [APMZ,2003] soll allerdings der Beginn dieser Isolierung des Hamster-Scrapiestammes 263K aus dem Maus-Scrapiestamm "Chandler" bereits in dem Artikel von Kimberlin und Marsh [AGLE,1975] beschrieben werden.
MH Age Factors; Animal; Brain/microbiology; Disease Models, Animal; Female; Hamsters; Hibernation; Male; Mesocricetus; Prions/*growth & development/pathogenicity; Scrapie/*microbiology/transmission; Sex Factors; Sheep; Spleen/microbiology; Splenectomy; Temperature; Virus Replication
SP englisch
PO England