NR AGKK
AU Kimberlin,R.H.; Field,H.J.; Walker,C.A.
TI Pathogenesis of mouse scrapie: evidence for spread of infection from central to peripheral nervous system.
QU Journal of General Virology 1983 Mar; 64 Pt 3: 713-6
PT journal article
AB The onset of replication has been studied in spinal cord, dorsal root ganglia and spinal nerves of CW mice infected intraperitoneally with the 139A strain of scrapie. The patterns obtained suggest a centrifugal spread of infection from central to peripheral nervous systems. Infectivity titres in the peripheral nervous system reached a plateau long before the end of the incubation period, and the maximum titres were much lower than in the central nervous system. This suggests that there is a restriction of replication in the peripheral nervous system similar to that already known in extraneural tissues.
IN Bei intraperitoneal inokulierten CW-Mäusen scheint sich der Scrapiestamm 139A vom zentralnervösen Rückenmark aus über die dorsalen Spinalganglien in das periphere Nervensystem zu wandern. Dort erreicht die Infektiosität lange vor dem Ende der Inkubationszeit ein maximales Plateau, welches aber weit unter dem des Zentralnervensystems liegt.
MH Animal; Brain/microbiology; Ganglia/microbiology; Mice; Peripheral Nervous System Diseases/*microbiology; Scrapie/etiology/*microbiology; Sheep; Spinal Cord/microbiology; Spinal Nerves/microbiology
SP englisch
PO England