NR AGIO
AU Kidson,C.; Moreau,M.C.; Asher,D.M.; Brown,P.W.; Coon,H.G.; Gajdusek,D.C.; Gibbs,C.J.Jr.
TI Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations
QU Proceedings of the National Academy of Sciences of the United States of America 1978 Jun; 75(6): 2969-71
PT journal article
AB Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection system, strandardized against fusion induced by Sendai virus. Correlation between the logarithm of virus dilution and the hybrid colony number gave similar curves for scrapie virus and Sendai virus. Fusion induction may explain some aspects of pathogenesis in these diseases and provide a potential in vitro assay.
IN Extrakte aus Scrapie-infizierten Hirnen bewirken ähnlich wie Sendai-Viren die Fusion von kultivierten Zellen.
MH Animal; Brain/microbiology; *Cell Fusion; Comparative Study; Creutzfeldt-Jakob Syndrome/*microbiology; Human; Pan troglodytes; Parainfluenza Virus 1, Human/physiology; Prions/*physiology; Scrapie/microbiology; Sheep
SP englisch
PO USA