NR AGFQ
AU Kato,S.; Hirano,A.; Umahara,T.; Kato,M.; Herz,F.; Ohama,E.
TI Comparative immunohistochemical study on the expression of alpha B crystallin, ubiquitin and stress-response protein 27 in ballooned neurons in various disorders
QU Neuropathology and Applied Neurobiology 1992 Aug; 18(4): 335-40
PT journal article
AB This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcinomatosis, anterior spinal artery syndrome and pellagra. Immunohistochemical techniques were used. alpha B Crystallin was expressed by the majority of ballooned neurons of Pick's disease and CJD, but not by those of the other disorders. Ubiquitin and srp 27 expression was also restricted to abnormal neurons of Pick's disease and CJD, but the proportion of stained cells was less than that expressing alpha B-crystallin. There was no evidence of ballooned neurons expressing srp 72. Except for those of pellagra patients, phosphorylated neurofilament protein (pNFP) was detected in most abnormal neurons. Our results suggest that the mechanisms involved in formation and maintenance of swollen neurons in Pick's disease and CJD may be different than those of ballooned neurons in the other entities studied.
IN alpha B Crystallin, Ubiquitin und das Streßreaktionsprotein 27 wurden immunologisch in geschwollenen Neuronen von Patienten mit der Creutzfeldt-Jakob-Krankheit oder der Pick-Krankheit, nicht jedoch bei Patienten mit amyotrophischer Lateralsklerose und drei weiteren Nervenkrankheiten nachgewiesen.
MH Aged; Comparative Study; Crystallins/*immunology/metabolism; Epitopes/immunology; Female; Heat-Shock Proteins/*immunology/metabolism; Human; Immunohistochemistry; Male; Middle Age; Nervous System Diseases/immunology/metabolism/*pathology; Neurofilament Proteins/metabolism; Neurons/immunology/*ultrastructure; Support, Non-U.S. Gov't; Ubiquitins/*immunology/metabolism
AD Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, Bronx 10467.
SP englisch
PO England