NR AGAA
AU Jendroska,K.; Hoffmann,O.; Schelosky,L.; Lees,A.J.; Poewe,W.; Daniel,S.E.
TI Absence of disease related prion protein in neurodegenerative disorders presenting with Parkinson's syndrome
QU Journal of Neurology, Neurosurgery and Psychiatry 1994 Oct; 57(10): 1249-51
PT journal article
AB Movement disorders presenting with parkinsonism may share histopathological features with Creutzfeldt-Jakob disease, a spongiform encephalopathy caused by the accumulation of pathological prion protein in brain. To investigate a possible aetiological link between these conditions and Creutzfeldt-Jakob disease, histoblot immunostaining for pathological prion protein was carried out in 90 cases including idiopathic Parkinson's disease, multiple system atrophy, diffuse Lewy body disease, Steele-Richardson-Olszewski syndrome, corticobasal degeneration, and Pick's disease. Pathological prion protein was identified in four controls with Creutzfeldt-Jakob disease but not in any of the other diseases examined. The findings suggest that an aetiological role for prions in these movement disorders is unlikely. Histoblotting provides a useful method for screening large areas of tissue for the presence of pathological prion protein and may be helpful in the differential diagnosis of difficult cases.
IN Das veränderte für die Creutzfeldt-Jakob-Krankheit typische Prionprotein konnte bei verschiedenen Formen der Parkinson-Krankheit nicht gefunden werden.
MH Brain/*pathology; Brain Diseases/pathology; Creutzfeldt-Jakob Syndrome/pathology; Dementia/pathology; Human; Immunohistochemistry; Nerve Degeneration; Parkinson Disease/*pathology; Prions/*analysis; Support, Non-U.S. Gov't; Supranuclear Palsy, Progressive/pathology
AD Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany. K Jendroska, Inst Neurol, UK Parkinson Dis Soc Brain Bank, 1 Wakefield St, London WC1N 3BG, England
SP englisch
PO England