NR AFYF
AU Jamieson,E.; Jeffrey,M.J.; Ironside,J.W.; Fraser,J.R.
TI Apoptosis and dendritic dysfunction precede prion protein accumulation in 87V scrapie
QU Neuroreport 2001 Jul 20; 12(10): 2147-53
PT journal article
AB The sequence of events involved in the neurodegeneration caused by transmissible spongiform encephalopathies (TSEs) is not yet known. Using a murine scrapie model in which neurodegeneration in the hippocampus is restricted to CA2, we show that pyramidal neuron damage and death by an apoptotic mechanism occur early in the incubation period, prior to the appearance of CA2 disease-specific accumulation of PrP and the onset of clinical disease. We suggest that the initial hippocampal pathological event in this model is dendritic dysfunction and activation of an apoptotic pathway rather than PrP accumulation.
MH Animal; Apoptosis/drug effects/*physiology; Dendrites/drug effects/*pathology; Disease Models, Animal; Genes, jun/drug effects; Hippocampus/drug effects/pathology; Immunohistochemistry; Mice; PrPsc Proteins/pharmacology; Prions/*metabolism; Pyramidal Cells/drug effects/pathology; Scrapie/*metabolism/*pathology; Support, Non-U.S. Gov't
AD Elizabeth Jamieson and Janet R. Fraser, Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UK; Martin J. Jeffrey (m.jeffrey@vla.maff.gov.uk), VLA Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 OPZ; James W. Ironside (james.ironside@ed.ac.uk), National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
SP englisch
PO England