NR AFYE
AU Jamieson,E.; Jeffrey,M.J.; Ironside,J.W.; Fraser,J.R.
TI Activation of Fas and caspase 3 precedes PrP accumulation in 87V scrapie
QU Neuroreport 2001 Nov 16; 12(16): 3567-72
PT journal article
AB The sequence of events involved in the neurodegeneration caused by transmissible spongiform encephalopathies is not yet known. Using a murine scrapie model in which neurodegeneration in the hippocampus is restricted to the CA2, we show an up-regulation of the proapoptotic markers Fas and caspase 3 early in the incubation period prior to disease-specific prion protein (PrP) deposition and clinical signs. These results suggest that activation of Fas and caspase 3 are involved in the early pathological sequence of events during murine scrapie, and that these proapoptotic markers may be a specific method for early detection of neurodegeneration.
MH Animal; Antigens, CD95/biosynthesis/*metabolism; Caspases/biosynthesis/*metabolism; Mice; Prions/*metabolism; Scrapie/*enzymology/*immunology/pathology; Support, Non-U.S. Gov't; Up-Regulation/immunology
AD Elizabeth Jamieson, Janet R. Fraser (janet.fraser@bbsrc.ac.uk), Institute for Animal Health, BBSRC and MRC, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK; Martin Jeffrey, VLA Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 OPZ; James W. Ironside, National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
SP englisch
PO England