NR AFST
AU Hunter,N.; Goldmann,W.; Benson,G.; Foster,J.D.; Hope,J.
TI Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie
QU Journal of General Virology 1993 Jun; 74(6): 1025-31
PT journal article
AB PrP glycoprotein gene polymorphisms were examined in Swaledale sheep affected by natural scrapie, in healthy sheep and in Swaledales selected for low susceptibility to scrapie. The three groups differed significantly in frequencies of PrP genotypes detected by the restriction enzymes EcoRI, HindIII and BspHI, the latter being indicative of a PrP protein amino acid difference at codon 136. These frequency differences were confirmed in a single-flock study and present good evidence that scrapie susceptibility and resistance are associated with PrP gene variants in Swaledale sheep.
MH Age Factors; Animal; Comparative Study; Deoxyribonuclease HindIII; Genetic Predisposition to Disease; Genotype; Immunity, Natural/genetics; Incidence; *Polymorphism (Genetics); PrPsc Proteins; Prions/*genetics; Restriction Mapping; Scrapie/*genetics; Selection (Genetics); Sequence Analysis, DNA; Sheep/*genetics; Species Specificity; Variation (Genetics)
AD Institute for Animal Health, AFRC/MRC Neuropathogenesis Unit, Edinburgh, U.K.
SP englisch
PO England