NR AFSS
AU Hunter,N.; Goldmann,W.; Smith,G.; Hope,J.
TI The association of a codon 136 PrP gene variant with the occurrence of natural scrapie
QU Archives of Virology 1994; 137(1-2): 171-7
PT journal article
AB Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of sheep). However Val136 does not correlate with incidence of scrapie in two other flocks - Poll Dorsets and Suffolks - and there may therefore be breed differences in PrP genotypes affected by scrapie.
ZR 22
MH Alleles; Animal; Codon/genetics; Genotype; Polymorphism (Genetics); Prions/*genetics/isolation & purification/pathogenicity; Reference Values; Scotland/epidemiology; Scrapie/*epidemiology/virology; Sheep; *Variation (Genetics)
AD Institute for Animal Health, BBSRC/MRC Neuropathogenesis Unit, Edinburgh, U.K.
SP englisch
PO Österreich