NR AFSQ
AU Hunter,N.; Goldmann,W.; Smith,G.; Hope,J.
TI Frequencies of PrP gene variants in healthy cattle and cattle with BSE in Scotland
QU The Veterinary Record 1994 Oct 22; 135(17): 400-3
PT journal article
AB Bovine spongiform encephalopathy (BSE) is one of a family of scrapie-like diseases which affect various mammals. Polymorphisms and mutations of the PrP gene have been associated with the incidence of experimental and natural scrapie in other animals and this study of the bovine PrP gene was undertaken to discover whether there was a similar association with PrP genotype in cattle with BSE. There are two known polymorphisms of the coding region of the bovine PrP gene, a silent HindII restriction site polymorphism and a difference in the number of an octapeptide repeated sequence (either five or six copies). An analysis of 370 cattle in Scotland revealed no difference between the frequencies of these PrP genotypes in healthy cattle and cattle with BSE.
MH Animal; Cattle/*genetics; DNA/analysis; Encephalopathy, Bovine Spongiform/*genetics; Female; *Gene Frequency; Genotype; Mutation; Polymorphism (Genetics)/genetics; Polymorphism, Restriction Fragment Length; Prions/*genetics; Scotland; Support, Non-U.S. Gov't; Variation (Genetics)/*genetics
AD Institute for Animal Health, Neuropathogenesis Unit, Edinburgh.
SP englisch
PO England
OR Prion-Krankheiten H