NR AFMZ
AU Hope,J.; Wood,S.C.E.R.; Birkett,C.R.; Chong,A.; Bruce,M.E.; Cairns,D.; Goldmann,W.; Hunter,N.; Bostock,C.J.
TI Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641
QU Journal of General Virology 1999 Jan; 80(1): 1-4
IA http://intl-vir.sgmjournals.org/cgi/content/abstract/80/1/1
ER Journal of General Virology 2000 Mar; 81(3): 851 in http://intl-vir.sgmjournals.org/cgi/content/full/81/3/851 (Korrektur) und http://www.socgenmicrobiol.org.uk/VIR/081/0851/0810851A.PDF
PT journal article
AB New variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform encephalopathy (BSE) are caused by the same strain of pathogen and, as sheep can develop experimental BSE, this has raised concern that humans may be at risk from eating mutton if BSE has naturally transmitted to sheep. Biochemical typing of abnormal prion proteins (PrPsc) has been suggested to detect BSE in sheep. Although this approach is ingenuous, we can now report biochemical evidence of strain variation in contemporary and archival brain tissue from cases of experimental BSE or experimental and natural scrapie in sheep. Interestingly, we found at least one isolate of natural scrapie (CH 1641) with a very similar, but not identical, PrPsc profile to BSE but which differs from BSE in its transmission characteristics to mice.
ZR 20 Zitate
VT
Korrektur:
Page 2, text line 9 should read '...for the record, this Mr for type B is 20200 (±800) for type A 24000 (±1300) and for type C
22700 (±1000). The glycoform ratios for each type were as follows: type B %H 66, %L 27; type A, %H 15-50, %L
22-46;... '
MH Animal; Cattle; Double-Blind Method; Encephalopathy, Bovine Spongiform/*etiology/pathology; Glycosylation; Mice; Prions/*classification/genetics/metabolism/physiology; Scrapie/*etiology/pathology; Sheep
AD BBSRC Institute for Animal Health, Compton Laboratory, Berkshire, UK. james.hope@bbsrc.ac.uk
SP englisch
PO England
EA pdf-Datei und Korrekturen