NR AFMJ
AU Holthoff,V.A.; Sandmann,J.; Pawlik,G.; Schröder,R.; Heiss,W.D.
TI Positron emission tomography in Creutzfeldt-Jakob disease
QU Archives of Neurology 1990 Sep; 47(9): 1035-8
PT journal article
AB Regional cerebral glucose metabolism was studied in a 73-year-old woman with autopsy-confirmed Creutzfeldt-Jakob disease, using positron emission tomography of 2-(18F)fluorodeoxyglucose. Regional absolute values were analyzed in 14 partially overlapping slices. Clinically, the patient was in an advanced stage of disease when positron emission tomographic scans revealed severe, diffuse hypometabolism, and neuropathological findings showed diffuse spongiform changes throughout the brain, with neuronal cell loss being obvious only in the cerebellum. Computed tomography was unremarkable for age, whereas the positron emission tomographic results were in accordance with histological findings and the patient's clinical condition. This article suggests that positron emission tomography depicts neuronal dysfunction rather than neuronal cell loss.
MH Aged; Brain/metabolism/pathology/radionuclide imaging; Case Report; Creutzfeldt-Jakob Syndrome/metabolism/pathology/*radionuclide imaging; Female; Glucose/metabolism; Human; *Tomography, Emission-Computed
AD Universitätsklinik für Neurologie, Köln, West Germany.
SP englisch
PO USA