NR AEYP
AU Guiroy,D.C.; Liberski,P.P.; Alwasiak,J.; Papierz,W.; Gajdusek,D.C.
TI Demonstration of amyloid beta-protein in a 32-year-old man with progressive dementia
QU Acta Neuropathologica 1991; 82(6): 523-6
PT journal article
AB We report the immunolocalization of extensive amyloid beta-protein in senile plaques, cerebrovascular amyloid deposits, neurofibrillary tangles and preamyloid in a 32-year-old man with progressive dementia not due to trisomy 21 or trauma. These amyloid deposits were non-reactive to antibodies directed against scrapie amyloid. Our data indicate that the presence of amyloid beta-protein is not limited to normal aging, Alzheimer's disease and related disorders but is also found in younger individuals with progressive dementia.
MH Adult; Amyloid beta-Protein/chemistry/*metabolism; Birefringence; Brain/metabolism/pathology; Case Report; Cerebellum/metabolism; Dementia/*metabolism/pathology/psychology; Human; Immunologic Techniques; Male; Staining and Labeling
AD Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
SP englisch
PO Deutschland