NR AEXY
AU Guentchev,M.; Voigtländer,T.; Haberler,C.; Groschup,M.H.; Budka,H.
TI Evidence for oxidative stress in experimental prion disease
QU Neurobiology of Disease 2000 Aug; 7(4): 270-3
PT journal article
AB Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
MH Animal; Biological Markers; Brain/*metabolism; *Disease Models, Animal; Glial Fibrillary Acidic Protein/*metabolism; Heme Oxygenase (Decyclizing)/metabolism; Mice; *Oxidative Stress; Prion Diseases/*metabolism; Support, Non-U.S. Gov't; Tyrosine/analogs & derivatives/metabolism
AD Austrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, Vienna, A-1097, Austria.
SP englisch
PO USA