NR AENK
AU Gibbs,C.J.Jr.; Asher,D.M.; Kobrine,A.; Amyx,H.L.; Sulima,M.P.; Gajdusek,D.C.
TI Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery
QU Journal of Neurology, Neurosurgery and Psychiatry 1994 Jun; 57(6): 757-8
PT journal article
AB Stereotactic multicontact electrodes used to probe the cerebral cortex of a middle aged woman with progressive dementia were previously implicated in the accidental transmission of Creutzfeldt-Jakob disease (CJD) to two younger patients. The diagnoses of CJD have been confirmed for all three cases. More than two years after their last use in humans, after three cleanings and repeated sterilisation in ethanol and formaldehyde vapour, the electrodes were implanted in the cortex of a chimpanzee. Eighteen months later the animal became ill with CJD. This finding serves to re-emphasise the potential danger posed by reuse of instruments contaminated with the agents of spongiform encephalopathies, even after scrupulous attempts to clean them.
IN Stereotaktische Multikontaktelektroden haben die Creutzfeldt-Jakob-Krankheit von einer mittelalten Frau auf zwei jüngere Patienten übertragen. Mehr als 2 Jahre nach der letzten Benutzung bei Menschen, nach 3 Reinigungen und mehrfacher Ethanol- und Formaldehyd-Dampfsterilisation wurden die Elektroden in das Gehirn eines Schimpansen implantiert. 18 Monate später erkrankte auch dieser an der Creutzfeldt-Jakob-Krankheit.
MH Animal; Case Report; Creutzfeldt-Jakob Syndrome/mortality/radiography/*transmission/*veterinary; *Electrodes, Implanted; *Equipment Contamination; Equipment Reuse; Ethanol; Female; Formaldehyde; Human; Iatrogenic Disease/prevention & control/*veterinary; Middle Age; *Pan troglodytes; *Stereotaxic Techniques; Sterilization/methods; Survival Rate; Zoonoses
AD Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
SP englisch
PO England