NR AENF
AU Giaccone,G.; Tagliavini,F.; Verga,L.; Frangione,B.; Farlow,M.R.; Bugiani,O.; Ghetti,B.
TI Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease
QU Brain Research 1990 Oct 22; 530(2): 325-9
PT journal article
AB In the Indiana kindred of Gerstmann-Sträussler-Scheinker disease, neurofibrillary tangles (NFT) with paired helical filaments (PHF) are numerous, widespread and consistently present in the cerebral cortex and several subcortical nuclei. Such tangles share antigenic determinants with those of Alzheimer disease; in fact, they are recognized by Alz50, anti-PHF and anti-ubiquitin antibodies. Thus, NFT with structural and immunocytochemical similarities are present in two distinct forms of amyloidosis of the central nervous system, i.e. the Indiana kindred of Gerstmann-Sträussler-Scheinker disease and Alzheimer disease.
MH Aged; Alzheimer Disease/immunology/*pathology; Brain/immunology/pathology; Female; Gerstmann-Sträussler-Scheinker Disease/immunology/*pathology; Human; Immunohistochemistry; Male; Middle Age; Neurofibrils/*immunology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Ubiquitins/immunology
AD Division of Neuropathology, Istituto Neurologico Carlo Besta, Milano, Italy.
SP englisch
PO Niederlande