NR AENC
AU Ghosh,S.
TI [Intestinal entry of prions]
OT Prioneneintritt über den Dünndarm
QU Zeitschrift für Gastroenterologie 2002 Jan; 40(1): 37-9
PT journal article
AB Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40 % of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.
MH Creutzfeldt-Jakob Syndrome/pathology/*transmission; Human; Intestinal Mucosa/*pathology; Intestine, Small/*pathology; Myenteric Plexus/pathology; Prions/*analysis; Protein Precursors/*analysis
AD Gastrointestinal Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK. s.ghosh@ic.ac.uk
AD Prof. S.Ghosh, Gastroenterology Section, Imperial College School of Medicine, Hammersmith Campus, London W12 0NN, s.gosh@ic.ac.uk
SP englisch
PO Deutschland
OR Prion-Krankheiten G