NR AELZ
AU Geiger,K.D.; Brecht,U.; Schober,R.; Schlote,W.
TI [Creutzfeldt-Jakob disease. Lack or correlation between cerebral cortex histology and clinical course of the disease in 22 autopsy cases]
OT Creutzfeldt-Jakob-Krankheit. Fehlende Korrelation zwischen zerebraler kortikaler Histologie und klinischem Verlauf der Erkrankung in 22 Obduktionsfallen.
QU Der Pathologe 2002 Jul; 23(4): 252-9
PT journal article
AB To detect a possible correlation between the neurology and duration of Creutzfeldt-Jakob disease (CJD) and cerebral pathology, we studied 22 autopsy cases by histological and immunohistochemical methods. The duration of disease ranged between 1 and 15 months with an average of 5.2 months. Only in 11 cases was the EEG typical for CJD. Morphologically the changes varied from minimal spongy changes to severe neuronal loss and brain atrophy. For the three cortical regions examined semiquantitatively, there was no correlation between the severity of spongiform changes and the duration of disease or the pattern of neurological symptoms. The study shows that more extensive sampling for the detection of regional heterogeneity of changes is mandatory in spongiform encephalopathies, and that complicating changes such as intermittent infections may play a role for the survival time as well. Moreover, genetic determinants, prion protein polymorphisms and the mode of exposure have to be considered as possible modulating factors.
MH Aged; Autopsy; Brain/pathology; Cerebral Cortex/*pathology; Child; Creutzfeldt-Jakob Syndrome/*pathology/*physiopathology; English Abstract; Female; Human; Male; Middle Age
AD Selbst. Abt. Neuropathologie, Institut für Pathologie, Klinikum der Universität Leipzig, Liebigstrasse 26, 04103 Leipzig. geik@medizin.uni-leipzig.de
SP deutsch
PO Deutschland