NR AEJH
AU Gallassi,R.; Morreale,A.; Montagna,P.; Gambetti,P.; Lugaresi,E.
TI "Fatal familial insomnia": neuropsychological study of a disease with thalamic degeneration.
QU Cortex 1992 Jun; 28(2): 175-87
PT journal article
AB Fatal Familial Insomnia (FFI) is an inherited disease characterized clinically by sleep, autonomic and motor disturbances and pathologically by marked atrophy of the anterior and dorsomedial nuclei of the thalamus. The neuropsychological study of three cases of FFI showed: (1) a progressive disturbance of attention and vigilance, (2) a memory deficit with lability of mnesic traces and difficulty in manipulation and ordering of events, suggesting an alteration of working memory and (3) a deficit of frontal abilities with impairment in planning and prevision of events but preservation of general intelligence.
MH Adult; Brain Diseases/*genetics/pathology/psychology; Case Report; Female; Flicker Fusion; Human; Intelligence Tests; Male; Memory/physiology; Middle Age; Nerve Degeneration; Psychological Tests; Psychomotor Performance; Sleep Initiation and Maintenance Disorders/*genetics/pathology/psychology; *Thalamus
AD Institute of Neurology, University of Bologna, Italy.
SP englisch
PO Italien