NR ADUY
AU Esmonde,T.F.G.; Will,R.G.
TI Creutzfeldt-Jakob disease in Scotland and Northern Ireland 1980-1989
QU Scottish Medical Journal 1992 Dec; 37(6): 181-4
PT journal article
AB The epidemiological and clinical features of Creutzfeldt-Jakob disease have never before been studied in Scotland and Northern Ireland. Case records for those dying with this diagnosis were obtained for the period 1980-89. Over the ten year period, 25 definite or probable cases were identified, giving an annual incidence of 0.37 cases/million. There were more cases in the second half of the decade, and this was most likely due to increased ascertainment. One pair of cases occurred in close proximity to each other. Sex distribution showed an excess of males (male:female ratio = 1.8:1). Mean age at onset was 65.2 years, and mean duration of disease was 5.3 months. The presenting symptoms and clinical features were similar to those noted in previous studies of other populations. There was no excess of cases in occupations linked to food, farming, or medical/paramedical work.
IN Eine statistische Untersuchung von allerdings nur 25 sicheren oder wahrscheinlichen Fällen von Creutzfeldt-Jakob-Krankheit in Schottland und Nordirland zeigt, dass nur etwa 1 Fall pro 1 Million Einwohner auftrat. Im Gegensatz zu anderen Studien fielen hier etwa doppelt so viele erkrankte Männer wie Frauen auf. Die Symptome traten durchschnittlich im Alter von 65 Jahren auf und führten im Mittel nach 5,3 Monaten zum Tode.
MH Aged; Case-Control Studies; Creutzfeldt-Jakob Syndrome/*epidemiology/physiopathology/therapy; Electroencephalography; Female; Human; Incidence; Male; Middle Age; Northern Ireland/epidemiology; Prospective Studies; Scotland/epidemiology; Support, Non-U.S. Gov't
AD Department of Clinical Neurosciences, Western General Hospital, Edinburgh.
SP englisch
PO Schottland