NR ADQM
AU Duguid,J.R.; Bohmont,C.W.; Liu,N.G.; Tourtellotte,W.W.
TI Changes in brain gene expression shared by scrapie and Alzheimer disease
QU Proceedings of the National Academy of Sciences of the United States of America 1989 Sep; 86(18): 7260-4
PT journal article
AB We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.
MH Alzheimer Disease/*genetics/metabolism; Animal; Base Sequence; Brain/*metabolism; *Genes, Structural; Glial Fibrillary Acidic Protein/*genetics; Glycoproteins/*genetics; Hamsters; Metallothionein/*genetics; Molecular Sequence Data; Nerve Tissue Proteins/*genetics; RNA, Messenger/genetics; Rats; Scrapie/*genetics/metabolism; Sequence Homology, Nucleic Acid; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; Transcription, Genetic; Transferrin/*genetics
AD Geriatric Research, Education and Clinical Center, Edith N. Rogers Memorial Veterans Hospital, Bedford, MA 01730.
SP englisch
PO USA