NR ADPO
AU Draganescu,N.; Girjabu,E.; Petrescu,A.; Anghelescu,N.; Marcutiu,V.; Ionescu,M.; Antipa,C.
TI Laboratory data on the experimental transmission of Creutzfeldt-Jakob disease in the guinea pig
QU Virologie 1981 Jul-Sep; 32(3): 207-9
PT journal article
AB Cerebrospinal fluid samples collected from 3 patients with Creutzfeldt-Jakob disease were inoculated intracerebrally to guinea pigs. After an incubation period of 4-14 months the animals developed a serially transmissible disease, characterized by loss of appetite, loss of weight, difficulty in movement, myoclonic convulsions and a fatal outcome within several days. The microscopic lesions caused by the experimental disease consisted in glial proliferation, spongiform change and vacuolation of the cytoplasm of proximal dendritic regions.
MH Animal; Brain/pathology; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/pathology/*transmission; Dendrites/pathology; *Disease Models, Animal; Guinea Pigs; Human; Neuroglia/pathology
SP englisch
PO Rumänien