NR ADNV
AU Donnelly,C.A.; Ferguson,N.M.; Ghani,A.C.; Wilesmith,J.W.; Anderson,R.M.
TI Analysis of dam-calf pairs of BSE cases: confirmation of a maternal risk enhancement.
QU Proceedings of the Royal Society B: Biological Sciences 1997 Nov 22; 264(1388): 1647-56
PT journal article
AB We investigate whether a calf born to a dam that develops bovine spongiform encephalopathy (BSE) (prior or subsequent to the birth) is itself at an enhanced risk of developing BSE. Analyses utilize the main database on reported BSE cases in the British cattle herd maintained by the Central Veterinary Laboratory in Weybridge to trace the dams of BSE-affected animals born following the ruminant feed ban in July 1988. The data reveal a significantly enhanced risk of disease in calves born to BSE-affected dams, with the risk being greatest when birth occurs after the onset of clinical signs of disease in the dam. The dependence of the maternally enhanced risk on the maternal incubation stage at birth argues for a significant component of direct maternal transmission of the aetiological agent of BSE, and offers little support for the hypothesis of genetic predisposition. Using a statistical likelihood model, we obtain estimates of the rate of direct maternal transmission by maternal incubation stage; however, biases in the available data make these values minimum estimates.
IN Anhand der vom Central Veterinary Laboratory in Weybridge geführten zentralen Datenbank über die britischen BSE-Fälle, ermittelten Donnelly et al. die Mütter von nach dem ersten britischen Verfütterungsverbot geborenen BSE-Rindern und deren Schicksal, um das BSE-Risiko britischer Rinder in Abhängigkeit vom BSE-Status ihrer Mütter zu erforschen. Sie fanden ein deutlich erhöhtes BSE-Risiko bei Rindern, deren Mütter ebenfalls an BSE erkrankten. Besonders stark erhöht war das BSE-Risiko der Kälber, wenn die Mütter schon vor deren Geburt an BSE erkrankten. Die verstanden ihre Daten als Unterstützung für die These einer maternalen Übertragung und hielten sie für kaum vereinbar mit der These der genetischen Prädisposition.
MH Animal; Cattle; Databases, Factual; *Disease Transmission, Vertical; Encephalopathy, Bovine Spongiform/epidemiology/genetics/*transmission; Female; Genetic Predisposition to Disease; Maternal Exposure; Models, Biological; Pregnancy; Risk Factors; Support, Non-U.S. Gov't
AD Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK. christl.donnelly@zoo.ox.ac.uk
SP englisch
PO England
OR Prion-Krankheiten D