NR ADLE
AU Diringer,H.; Ehlers,B.
TI Chemoprophylaxis of scrapie in mice
QU Journal of General Virology 1991 Feb; 72(2): 457-60
PT journal article
AB Three applications of the polyanion pentosanpolysulphate about 2 months before infection of mice with scrapie completely protected animals infected with up to 100 LD50, and considerably prolonged the lifespan of those infected with 100 to 10,000 LD50. The clinical diagnosis was confirmed by immunoblot analysis for the protein of scrapie-associated fibrils.
IN Das Polyanion Pentosanpolysulphat scheint Mäuse gegen eine Scrapie-Infektion zu immunisieren und verlängert die Überlebenszeit infizierter Mäuse.
MH Animal; Brain Chemistry; Immunoblotting; Mice; Nerve Tissue Proteins/analysis; Pentosan Sulfuric Polyester/*therapeutic use/toxicity; PrP 27-30 Protein; Scrapie/drug therapy/*prevention & control
AD Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Germany.
SP englisch
PO England