NR ACOH
AU Chernoff,Y.O.; Lindquist,S.L.; Ono,B.; Inge-Vechtomov,S.G.; Liebman,S.W.
TI Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]
QU Science 1995 May 12; 268(5212): 880-4
PT journal article
AB The yeast non-Mendelian factor [psi+] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [psi+] factor. Over-production or inactivation of Hsp104 caused the loss of [psi+]. These results suggest that chaperone proteins play a role in prion-like phenomena, and that a certain level of chaperone expression can cure cells of prions without affecting viability. This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity.
IN Die nicht genetisch bestimmte Eigenschaft psi(+) bei Hefe scheint wie bei den Prion-Krankheiten durch eine Umfaltung eines Proteins bewirkt zu werden. Dazu ist anscheinend das Chaperon-Protein hsp104 erforderlich, wobei weder zu wenig, noch zu viel von diesem Chaperon-Protein vorhanden sein darf.
ZR 48
MH Fungal Proteins/*biosynthesis/genetics/physiology; Gene Expression; Heat-Shock Proteins/genetics/*physiology; Mutation; Prions/*biosynthesis; Saccharomyces cerevisiae/genetics/*physiology; Support, Non-U.S. Gov't; Suppression, Genetic
AD Department of Biological Sciences, University of Illinois, Chicago 60607-7020, USA
SP englisch
PO USA