NR ACNY
AU Cherednichenko,Iu.N.; Mikhailova,G.R.; Sologub,V.K.; Vanag,K.A.
TI [Morphological characteristics of the brain lesions in mice infected with a homogenate of L cells latently infected with the scrapie agent]
OT Morfologicheskie osobennosti porazhenii mozga myshei, zarazhennykh gomogenatom kletok L, latentno infitsirovannykh agentom skrepi
QU Voprosy Virusologii 1985 Sep-Oct; 30(5): 589-94
PT journal article
AB Degeneration of neurons of the Ammon horn lower branch both in the early and terminal stages of the disease of mice infected with the homogenate of L cells latently infected with the scrapie agent (the L-S system) was frequently detected alongside with brain lesions typical of slow infections (vacuolation). Examinations of chromosomes in metaphase plates of L-S cells carried out by several methods including the TAC system for texture analysis of the image (Leutz, BRD) revealed three marker chromosomes new for continuous L cells, the appearance of true chromatid translocations as well as significant changes in chromosome numbers. Besides, ultrastructural features of L-S cells at later stages of cultivation were revealed. It is assumed that the active effect of the scrapie agent on L cells infected with it resulted in the emergency of a new antigen capable to induce selective affection of the neurons of the Ammon horn lower branch in susceptible mice.
MH Animal; Brain/*pathology/ultrastructure; Comparative Study; Encephalitis, Japanese/pathology; English Abstract; L Cells (Cell Line)/*microbiology/ultrastructure; Measles/pathology; Metaphase; Mice; Mice, Inbred BALB C; Microscopy, Electron; Poliomyelitis/pathology; Rabies/pathology; Scrapie/*pathology; Smallpox/pathology; Virus Cultivation
SP russisch
PO Sowjetunion