NR ACNF
AU Chatelain,J.C.; Millot,P.; Bourdon,R.; Callebert,J.; Faudon,R.; Grolleau,D.; Trouillet,D.
TI Diverse biological parameters in clinically healthy sheep from a flock with scrapie: variations, and correlations with OLA antigens.
QU Experimental and Clinical Immunogenetics 1992; 9(2): 86-94
PT journal article
AB A comparison was made in the blood levels of various cell types and biochemical substances and in lymphocyte antigens between 107 healthy sheep from a flock contaminated with scrapie (HC sheep) and 93 sheep from a noncontaminated flock (NC sheep), which served as a control population. Significant differences between the two groups of sheep were found in some of the levels, as had previously been found with lymphocyte antigens. The HC sheep, which included genetically resistant animals, could be distinguished from the NC sheep by their lower levels of various white cells, a noticeable decrease in urea, a moderate decrease in Mg2+ and Mn2+ ions, beta- and gamma-globulins, serotonin and vitamin B12, a strong increase in uric acid and a moderate increase in K+, Cl-, HCO3-, Zn2+, and Al3+ ions, as well as in total lipids and in the albumin to globulin ratio. In this HC population, the only enzyme with an increased level was aldolase; the levels of the other 7 enzymes measured were lowered. The observed modifications were considered to be signs of latent disturbances in the leukocyte system and in hepatic and renal functions, in spite of apparent resistance. Eleven lymphocyte antigens were studied. These antigens are not independent of the blood levels of the various substances measured, but are often correlated in a statistically significant manner with some of them. In the HC sheep, the lymphocyte antigens correlated with the modified levels in the blood were different from those in the control population.(ABSTRACT TRUNCATED AT 250 WORDS)
IN Ein Vergleich von 107 gesunden Tieren einer scrapieinfizierten Schafherde mit 93 Schafen einer scrapiefreien Herde zeigte im Blut der anscheinend bereits infizierten Schafe verminderte Leukozytenzahlen, eine merklich reduzierte Harnstoffkonzentration, moderat erniedrigte Konzentrationen von Magnesium- und Manganionen, beta- und gamma-Immunglobulinen, Serotonin und Vitamin B12, eine starke Zunahme der Harnsäure und eine moderate Zunahme von Kalium-, Clorid-, Hydrogencarbonat-, Zink- und Aluminiumionen. Außerdem waren das Verhältnis von Lipiden zu globulären Plasmaproteinen sowie das Verhältnis von Albumin zu allen globulären Plasmaproteinen verändert. In der Scrapie-Herde wurde im Blut nur eine erhöhte Aldolaseaktivität ermittelt, während 7 andere gemessene Enzyme reduziert waren. Die Autoren deuten ihre Befunde als Anzeichen für eine latente Störung des Leukozytensystems sowie der Leber- und Nierenfunktionen.
MH Animal; Blood Chemical Analysis; Disease Susceptibility/immunology; Enzymes/blood; Histocompatibility Antigens/*blood/*genetics; Leukocyte Count; Lymphocytes/immunology; Scrapie/blood/*immunology/pathology; Sheep
AD FRA Claude Bernard Neurochimie des Communications Cellulaires, Service de Biochimie, Hopital Saint-Louis, Paris, France.
SP englisch
PO Schweiz