NR ACMX
AU Chapman,T.; McKeel,D.W.Jr.; Morris,J.C.
TI Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease
QU Neurology 2000 Nov 14; 55(9): 1396-7
KI Neurology. 2001 Apr 10;56(7):986-7. PMID: 11294951
PT journal article
AB The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
MH Adult; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid; False Negative Reactions; Female; Human; Male; Middle Age; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Tyrosine 3-Monooxygenase/*cerebrospinal fluid
AD Washington University School of Medicine, St. Louis, MO 63110, USA
SP englisch
PO USA