NR ACMK
AU Chang,J.; Rohwer,R.G.
TI Clostridium difficile infection in adult hamsters
QU Laboratory Animal Science 1991 Dec; 41(6): 548-52
KI Laboratory Animal Science 1992 Feb;42(1):4. PMID: 1316508
PT journal article
AB Diarrhea was encountered in a group of adult female golden Syrian hamsters (Mesocricetus auratus) used for titrating the scrapie agent. Ninety percent of the cases occurred in animals over 210 days old even though animals of all age groups lived in the colony concurrently. The cause of diarrhea was investigated in both uninoculated animals and those receiving greater than a limiting dilution of scrapie infectivity, i.e., animals that were not expected to contract the experimental scrapie disease. Three forms of diarrhea were observed. The most commonly encountered was profuse and watery. A chronic form presented with semiformed, thin fecal material smearing the retroperitoneal region. Hemorrhagic diarrhea was observed rarely. Mortality was high among animals with acute watery or hemorrhagic diarrhea. Animals with semiformed soft stools were dehydrated, had a roughened hair-coat, and hunched back. Cardinal lesions were necrosis, inflammation, and mucosal hyperplasia of the cecum and colon and cholangiohepatitis with amyloid deposition. Diffuse renal amyloidosis was present in chronic cases. Toxigenic, cytotoxin B-positive Clostridium difficile was isolated from a majority of affected animals. Cytotoxin B was also present in cecal homogenates of diarrheic animals with C. difficile. The pathological and microbiologic findings indicated a typhlitis and colitis in adult hamsters that was associated with C. difficile infection.
IN Bei unter dem Streß einer Gruppenhaltung lebenden weiblichen, syrischen Goldhamstern (Mesocricetus auratus) scheint die bei diesen Hamstern übliche Infektion mit Clostridium difficile im Alter von mehr als 210 Tagen zu einem häufig tödlichen Durchfall zu führen. Die Tiere bekommen ein struppiges Fell, einen krummen Rücken und neben einer Schädigung des Darmes auch eine Entzündung von Leber und Gallengängen mit amyloidartigen Ablagerungen. Bei chronischen Fällen wurde eine diffuse Amyloidose auch in den Nieren gefunden.
MH Animal; Bacterial Toxins/biosynthesis; Clostridium difficile/isolation & purification/metabolism; Cytotoxins/biosynthesis; Diarrhea/etiology/pathology; Enterocolitis, Pseudomembranous/*etiology/pathology; Female; Hamsters; *Mesocricetus; Support, U.S. Gov't, P.H.S.
AD Division of Laboratory Animal Medicine, School of Medicine, University of North Carolina, Chapel Hill 27599.
SP englisch
PO USA
ZF kritische Zusammenfassung von Roland Heynkes