NR ACHB
AU Carrell,R.W.; Gooptu,B.
TI Conformational changes and disease - serpins, prions and Alzheimer's
QU Current Opinion in Structural Biology 1998 Dec; 8(6): 799-809
PT journal article; review; review, tutorial
AB Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.
ZR 59
MH Alzheimer Disease/*metabolism; Amyloid beta-Protein/chemistry; Animal; Human; Prion Diseases/*metabolism; Prions/*chemistry; Protein Conformation; Serpins/*chemistry; Support, Non-U.S. Gov't
AD Robin W. Carrell (rwc1000@cam.ac.uk), Department of Haematology Cambridge Institute for Medical Research University of Cambridge Hills Road Cambridge CB2 2XY UK
SP englisch
PO England