NR ACDJ
AU Caboclo,L.O.S.F.; Huang,N.; Lepski,G.A.; Livramento,J.A.; Buchpiguel,C.A.; Porto,C.S.; Nitrini,R.
TI Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report.
QU Arquivos de Neuro-Psiquiatria 2002 Jun; 60(2-B): 458-61
IA http://www.scielo.br/pdf/anp/v60n2B/10212.pdf
PT case reports; journal article
AB We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.
IN Aus Brasilien wird ein zweiter Fall von Creutzfeldt-Jakob-Krankheit bei einem mit menschlichen Wachstumshormonen behandelten Menschen gemeldet.
MH Adult; Blotting, Western; Cerebrospinal Fluid Proteins/*analysis; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/diagnosis/*etiology; Human; Human Growth Hormone/*adverse effects/therapeutic use; *Iatrogenic Disease; Magnetic Resonance Imaging; Male; Tyrosine 3-Monooxygenase/cerebrospinal fluid
AD Luís Otávio Sales Ferreira Caboclo, Nancy Huang, Cláudia Sellitto Porto, Guilherme Alves Lepski, José Antônio Livramento (Laboratory of Neurological Investigation), Carlos Alberto Buchpiguel (Department of Radiology), Ricardo Nitrini, Department of Neurology, University of São Paulo Medical School, Rua Bartolomeu Feio 560 - 04580-001 São Paulo SP, Brazil
SP englisch
PO Brasilien