NR ACCV
AU Buyukmihci,N.C.; Goehring-Harmon,F.; Marsh,R.F.
TI Retinal degeneration in experimental scrapie after intraperitoneal or subcutaneous inoculation of hamsters
QU Experimental Neurology 1985 May; 88(2): 461-6
PT journal article
AB Hamsters injected intraperitoneally or subcutaneously with the scrapie agent developed photoreceptor degeneration. The degree of degeneration did not correlate well with infectivity titers of retinal tissue or stage of clinical encephalopathy, and was not as great as seen in intracerebrally injected animals. We conclude that retinal degeneration is universal in hamsters experimentally inoculated with the scrapie agent regardless of the route of inoculation.
MH Animal; Brain/microbiology; Hamsters; Optic Nerve/microbiology; Prions/isolation & purification; Retina/microbiology/pathology; Retinal Degeneration/pathology; Retinal Diseases/*etiology; *Scrapie; Sheep; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
SP englisch
PO USA